1Assistant Professor, Biochemistry, LN Medical College, Bhopal, MP
2Assistant Professor, Anaesthesia, LN Medical College, Bhopal, MP
3Professor, Biochemistry, LN Medical College, Bhopal, MP
Online published on 26 April, 2016.
Dyslipidemia contributes to the high risk of CVD in CKD. Measuring the ratios of LDL/HDL, TC/HDL and TG/HDL is better than just detecting dyslipidaemia, particularly when LDL levels are not elevated. Since a very large number of patients have early asymptomatic CKD, it is necessary to do a stage wise comparison of the atherogenic risk. This study was therefore carried out to study the relationship of the atherogenic lipid ratios with severity of CKD and the corresponding decline in GFR.
KFT, GFR and lipid profile were estimated in four age and sex matched groups i.e. 3 groups of CKD severity based on the decline in their GFR, having 19, 42 and 39 patients respectively; and a group of 100 healthy controls. Group comparison of the atherogenic lipid ratios was done. Correlation of plasma lipids and lipid ratios with KFT and GFR was obtained.
CKD patients had significant dyslipidaemia, particularly hypertriglyceridaemia with reduced HDL, but no significant alteration in LDL. Atherogenic lipid ratios were increased in all stages of CKD compared to controls. Of these, TG/HDL was the most effective, showing significant difference in both the middle and the later stages from the earlier stages. GFR correlated positively with HDL and negatively with triglycerides, TG/HDL and TC/HDL.
Risk of CVD is high even at the earlier stages of CKD and this risk is best measured by the TG/HDL ratio
CKD, CVD, Dyslipidemia, Atherogenic lipid ratios
