1Assistant Professor, Dept of Pathology, Hassan Institute of Medical Sciences (HIMS), Hassan
*Corresponding author: Dr. Vijay P M Assistant professor, Dept of Pathology, HIMS, Hassan
Online published on 4 July, 2016.
Malignant pigmented villonodular synovitis (MPVNS) is a rare lesion whose existence may be debatable. We studied 10 cases of malignant pigmented Villonodular synovitis among the age group of 20-40yrs. Females dominated males in the incidence & wrist was the commonest joint involved presenting with pain & swelling in most of our cases & only 2 paitents had restricted movements. In 3 cases MPVNS was found to be arising from the previous cases of benign PVNS & 7 cases were primary with histological features similar to that of secondary. Most of the MPVNS showed histological features like nodular, solid infiltrative pattern of the large, plump, round or oval cells with deep eosinophilic cytoplasm and indistinct borders, large nuclei with prominent nucleoli, and necrotic areas. Atypical mitoses were frequent about more than 10/10hpf. 3 cases showed immunoreactivity for CD68, CD163, and vimentin. 3 cases recurred & died of pulmonary metastasis & inguinal lymph node metastasis in a span of 2 yrs.
The malignant nature of this lesion, the histologic architecture similar to that of PVNS, and the fibrohistiocytic appearance of the cells suggest that malignant PVNS is an entity. Thus corroborative evidence of clinical, pathological, radiological & immunohistochemical findings are essential in arriving at a definitive diagnosis & treatment of MPVNS.
MPVNS, D-TGCT, osteoclast like giant cells, atypical mitotic figures, solid infiltrative, plump cells
