1Assistant Professor, Molecular Reproduction and Human Genetics Laboratory, Dept. of Studies in Zoology, University of Mysore, Manasagangothri, Mysore
2Guest Faculty, Dept. of Studies in Zoology, University of Mysore, Manasagangothri, Mysore
3Forensic Expert & Clinical Toxicologist, Dept of Forensic Medicine & Toxicology, District Hospital, Chamarajanagar, Karnataka
*Corresponding author: Dr. Suttur S Malini Assistant Professor, DOS in zoology, University of Mysore, Manasagangothri, Mysore-06, India, Email: ssmalinisri@yahoo.co.indrssmalini@gmail.com
Online published on 14 October, 2016.
Major cause of neonatal and infant mortality is caused due to congenital anomalies especially in developing countries, accounting for around 30% of infant deaths. Low socio-economic condition and educational status play an important role in increased risk of still birth, congenital anomalies, and preterm labour and fetal death rates. Among other socio-economic disparities, determinants, such as low body mass index (BMI), inadequate weight gain during pregnancy, poor nutrition and short stature are all associated these risks. Understanding, how these factors are relating to congenital anomalies arise is key to implementing effective public health interventions to reduce socioeconomic inequalities in infant and neonatal mortality.
In the present study, the author has quantified the effects of different demographic factors on the prevalence of babies with abnormalities and to analyze the education and socioeconomic factors related to pregnancy outcome and neonatal mortality in association with congenital anomalies in Mysore population. In the present study a total of 691 chromosomal aneuploidy cases were collected from different hospitals of Mysore city over a period of 20 years from 1989–2009. To generate case-control data set randomly selected 700 healthy children from different religions, localities and hospitals in and around Mysore city were used. Logistic regression was performed using the software, SPSS version 10.0 to record the effect of the variables in both controls and cases. Out of 7, 20, 000 babies691 are born with chromosomal abnormalities and Down syndrome stands first with 82.77% among them whereas cri-du chat is least prevalent accounting for 0.28%. Parental education, parents from Urban area, education of the parents and prenatal diagnosis showed significant difference in the odds ratios. These studies indicate that medical awareness is essential for each parent whether they belong to urban or rural regions and proper prenatal diagnosis has to be implemented in all health care centers both in rural and urban areas.
Parental education, Prenatal diagnosis, Abnormal children
