Role of MRI and MR Spectroscopy in Carcinoma Prostate

Prostate cancer (PCa) is a high-profile disease due to its incidence, the large number of men dying yearly from the disease, the considerable debate surrounding the benefit and risks of early detection, and the amount of research currently ongoing in its detection, diagnosis and management. PCa is now recognized as one of the most important medical problems facing the male population.

Present study aim to see for capability of MR imaging in diagnosing prostate carcinoma in patients with raised PSA level. To asses role of MR for staging and extension of carcinoma prostate in biopsy proven cases. Correlation of MR spectroscopy findings with MRI findings in carcinoma prostate.

The present study was conducted in the Department of Radiodiagnosis, SVBP Hospital, LLRM Medical College Meerut, Department of Radiodiagnosis, Muzaffarnagar Medical College, Muzaffarnagar, and Om Imaging and Diagnostic Centre, Meerut. Type of study-Prospective Analytical-Observational study. With Informed consent for our study, we identified 40 consecutive patients who, from January 2014 to July 2015 underwent combined preoperative MR imaging and proton MR spectroscopic imaging performed with commercially available acquisition and processing software and for whom histopathologic maps were available for comparison with imaging findings.

The 12 prostatic areas were combined into apex, base, central, and peripheral zone to facilitate statistical calculations. Histopathologic analysis Pathological examination of RP specimens detected cancer foci in 96 areas out of a total of 160 areas (40 patients multiplied by 4 areas).

The role of MRI and MR spectroscopy in carcinoma prostate which were confirmed for carcinoma prostate on biopsy. Based on the observations made in the course of the study, the following conclusion was made that with high sensitivity and high positive predictive value MRI is quite accurate in diagnosing and looking for the extent of the carcinoma. Proton MR spectroscopy of human prostatic tissue can depict subtle chemical differences associated with different cellular component.