Prevention of Post-Operative Nausea and Vomiting Using Granisetron and Ondansetron in Laparoscopic Surgeries in a Comparative Clinical Study

Postoperative nausea and vomiting is one of the most common complication dispite of advances made in anaesthesia. The efficacy of granisetron with that of ondansetron as antiemetic is compared in 90 patients undergoing laparoscopic surgeries. The patients were devided into three groups of 30 patients each. In group-G, patients received 40 mcg/kg granisetron intravenously 3 min before induction. Group-O patients received 80 mcg/kg ondansetron intravenously 3 min prior to induction while group-C patients received 3 ml of 0.9% normal saline as control. All the patients were selected for general anaethesia and observations in the Department of Surgery & Anaesthesia of Rama Medical College & Hospital Pilakhwa Hapur, were made for pulse rate, blood pressure, nausea, vomiting and side effects of the drugs under study upto 12 hours postoperatively. The frequency of nausea was 10%, 30% and 40% in group-G, group-O and group-C respectively. The statistical analysis shows that granisetron is better for prevention of post-operative nausea and vomiting (PONV)in comparison to ondansetron and is highly significant in comparison to control group. As far as the side effects of the drugs are concerned, postoperative headache, dizziness, diplopia and shivering was significantly higher in ondansetron groups.

Thus from the present study, it is concluded that intravenous granisetron 40 mcg/kg intravenously is superior to ondansetron 80 mcg/kg as a prophylactic antiemetic in laparoscopic surgeries in controlling PONV.