1Associate Professor, Paediatrics, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar
2Assistant Professor, Microbiology, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar
*Address for Correspondence: Natabar Swain Associate Professor, Dept of Pediatrics, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, PIN: 751024, E mail: natabarswain@gmail.com
Online published on 11 April, 2017.
Typhoid fever is considered as one of the most serious infectious disease and threat to public health on a global scale, especially in developing countries, with particular concern over the rapid and widespread emergence of resistant Salmonella Typhi to multiple antibiotics. Hence it becomes imperative to assess the extent of drug resistance before treatment is administered. Present study was aimed to analyze the profile of typhoid fever, its different complications and antibiotic sensitivity pattern in a tertiary care setting. A retrospective study of clinical and lab profile was carried out with 105 culture positive pediatric cases during Jan 2013 to Dec 2015; result was analysed which revealed return of sensitivity to old antibiotics i.e. Ampicillin, Co-trimoxazole, highest sensitivity to Cephalosporins, better sensitivity to Ciprofloxacin, total resistance to Aminoglycosides, increased resistance to Nalidixic acid and return of sensitivity of Nalidixic Acid Resistant S. Typhi (NARST) to Ciprofloxacin.
Typhoid fever, Multi drug resistance, NARST, Sensitivity Pattern
