1Division of Respiratory and Critical Illnes, Internal Medicine Departement, Faculty Medicine University of Indonesia, Jakarta, Indonesia
*Corresponding author: Zulkifli Amin, Diponegoro Street 71, Central Jakarta, Indonesia Phone +62 21 314 9704, e-mail: zulkifliamin52@gmail.com
Online published on 11 April, 2017.
Using ‘STOP TB’ strategy, World has succeed decreasing TB case and mortality rate. Neverthless, both numbers remains high. By this study, we aimed to find any natural products could be used as adjunctive tuberculosis therapy in order to achieve better treatment result.
Review related articles found from Pubmed, Google Scholar, cochrane, and personal databases.
There was five natural products (Dzherelo, Curcumin, Cathecin, Jawarish amla, and Chinesse herbal medicine) showed promising result when used as adjunctive to standard antituberculosis therapy. Dzherelo, curcumin, and CHM enhanced sputum conversion and improved lung lesions. Dzherelo and cathecin reduced free radicals agent. All herbals, except CHM is reported alleviating adverse antituberculosis drugs effects. Additionally, dzherelo also could modulated humoral and cellular immune system.
Inadequate drug regimens for treating TB cases, poor adherence due to long duration of therapy and adverse drug reaction, and uncompetent immune system can lead to treatment failured. Using herbal products as adjunctive tuberculosis therapy could improved tuberculosis treatment result.
As adjuvant therapy, dzherelo and curcumin products are superior than others herbal products, but further investigation still needed.
Natural products, Plants, Tuberculosis, Adjunctive therapy, Sputum conversion
