1Nursing Department, STIKES Tanawali Persada Takalar. Makassar, Indonesia
2Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Indonesia
3Department of Obstetric and Gynecology, Faculty of Medicine, Hasanuddin University. Makassar. Indonesia
4Molecular Biology and Immunology Laboratory. Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
5Nursing Department, STIK Famika Makassar, Indonesia
6Nursing Department Faculty of Nursing, Hasanuddin University, Indonesia
*Corresponding author: Salmah Arafah Nursing Department, STIKES Tanawali Persada Takalar, Makassar, Indonesia Email Id: salmaharafah@yahoo.co.id
Online published on 7 February, 2018.
This study aims to determine the expression of mRNA MCP-1 gene in Preeclampsia Patients.
The research method used is quantitative research using case-control design with the sample of 20 respondents consisting 10 cases and 10 controls. Case samples were pregnant women with preeclampsia at the time of the study while control samples were normal pregnant women who met inclusion and exclusion criteria. Data were analyzed using Independent T-Test statistics.
The results showed that 95% CI with LL =-6, 465 and UL =-4, 852, with p = 0, 000 mean that average expression of mRNA MCP-1 gene in blood expressed was higher in preeclampsia group. While 95% CI value with LL =-6, 371 and UL =-4, 688, with p value = 0.000 mean that average expression of mRNA MCP-1 gene on exposed placenta is also higher in preeclampsia group.
It is necessary to follow up with prospective cohort design by making the class of pregnant mothers at risk with guidance for preeclampsia and determine of profile mRNA expression MCP-1 gene in both blood and placenta as molecular pathophysiology.
Preeclampsia, MCP-1, mRNA
