Relationships of B-RAF Immuno-expression with Clinic Pathological Features in Patients with Colorectal Carcinoma in Wahidin sudirohusodo Hospital Makassar

Colorectal Cancer is a malignancy that is due in addition to environmental factors, as well as genetic mutations. Oncogene mutation of B-RAF V600E plays an important role in the cascade of intracellular signaling pathways barriers mitogen-activated kinase protein in colorectal cancer. B-RAF mutations in colorectal cancer ranges from 5–20%. The purpose of this study was to determine immune-expression B-RAF V600E against clinic pathologic overview of colorectal cancer.

This research is an analytic cross-sectional study on 40 cases of colorectal carcinoma cases. Immune-hystochemical staining of the B-RAF V600E thin piece of the tumor mass to evaluate their immune-expression B-RAF V600E and Chi-square test. Data were analyzed with SPSS 15.0 For Windows to determine the relationship immune-expression B-RAF with clinic pathologic. Then the data were tested using Spearman's statistical test.

Significance is determined by the value of P <0.05. Of the 40 patients with carcinoma colorectal the staining immune-expression B-RAF V600E association remained immune-expression B-RAF V600E against gender (p = 0.041), tumor location (p = 0.020), TNM staging (p = 0.011) and the degree of differentiation (p = 0.023) but no significant relationship between immune-expression B-RAF and histopathological picture (p = 0.090).

Immune-expression B-RAF significantly associated with clinic pathologic features of colorectal carcinoma and these data show immune-expression B-RAF V600E can be used as a standard clinical and pathological for better treatment against colorectal carcinoma.