Indian Journal of Public Health Research & Development
  • Year: 2018
  • Volume: 9
  • Issue: 10

Association of TNF-α with fasting glucose, insulin and insulin resistance in complete glycemic spectrum

1Ph. D. Scholar, Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India

2Professor and Head, Department of Physiology, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh

3Professor-Head, Department of Radiology, JIPMER

4Additional Professor, Department of Medicine, Dr Nandeesha H, JIPMER

5Associate Professor, Department of Biochemistry, JIPMER

*Corresponding author: Dr. Vivek Kumar Sharma, Professor and Head, Department of physiology, Government Institute of Medical Sciences, Greater Noida, U.P-201310. Mobile: 9442529673. Email: drviveksharma@yahoo.com.

Online published on 1 November, 2018.

Abstract

The aim of the present study is to assess fasting glucose, fasting insulin, insulin resistance, and inflammation in complete glycemic spectrum and to study the association between them if any.

Participants (30–50 years) of either gender were enrolled. Based on their family history of diabetes and glucose levels, they were grouped into normoglycemic non-first-degree relatives of diabetes, normoglycemic first degree relatives of diabetes, Prediabetes and diabetes. Fasting Glucose, Fasting insulin and Tumor necrosis α (TNF-α) concentrations were analyzed. Groups were compared using one-way ANOVA with LSD posthoc analysis. Correlation between the parameters were done using Pearson's correlation and linear regression analysis.

We observed that fasting insulin, fasting glucose, TNF-α, and HOMA2 IR gradually increased as we moved along the glycemic spectrum from control, FDRD, prediabetes to diabetes, while HOMA2%S gradually decreased. HOMA2%B-there is an increase in FDRD as compared to controls, but it decreased in prediabetes and diabetes as compared to FDRD or controls. There was positive correlation between TNF-α and fasting glucose across the glycemic spectrum and no correlation with fasting insulin or insulin resistance.

Inflammation begins even in first degree relatives of diabetes and increases along with glucose levels along the glycemic spectrum.

Keywords

First degree relatives of diabetes, prediabetes, HOMA2%B, HOMA2%S, HOMA2IR, HOMA-IR