1Professor of physiology, Department of physiology, Collage of Medicine, University of Kufa, Najaf Ashraf, Republic of Iraq
2Professor of Physiology, Department of physiology, Collage of Medicine, University of Kufa, Najaf Ashraf, Republic of Iraq
3Resident Physician of Medicalphysiology, Collage of Medicine, University of Kufa, Najaf Ashraf, Republic of Iraq
*Corresponding author Sami R. Al-Katib E-mail: jabirbhn3@gmail.com
Online published on 1 November, 2018.
Psoriasis is a chronic inflammatory skin disease that has been associated with abnormal plasma lipid metabolism and oxidative stress.
To assess the anti-oxidative effect of vitamin C supplementation in psoriasis patients treated by NB-UVB phototherapy and its correlation with the disease severity.
A single blind randomized clinical trial included 74 patients with clinically diagnosed psoriasis, conducted at AL-Sadr Medical city and department of Laser research in AL-Najaf City during a period one year. The patients were assigned randomly in to two groups be treated with NB-UVB only or NB-UVB+V.C supplementation of (500mg) twice daily for 12 week and followed up to assess their responses.
Vitamin C and GSH were significantly increased while serum level of MDA significantly reduced, (p<0.05) in NB-UVB+V.C compared to NB-UVB only group. A significant decrease in GSH and increase in MDA (p<0.05). A statistically significant correlation (positive) was found between V.C and GSH and negative correlation was found between V.C and MDA levels after treatment(P<0.05) in NB-UVB+V.C group. PASI score was insignificantly correlated with V.C, GSH and MDA, (P>0.05).
Vitamin C supplementation has a significant role as a safe anti-oxidant in psoriatic patients treated by NB-UVB phototherapy.
Psoriasis, Vitamin C, GSH, MDA, Oxidative stress
