University of Babylon, College of Medicine, Hillah, Iraq
Online published on 1 November, 2018.
Polycythemia vera (PV) is a hematopoietic disturbance involving uncontrolled proliferation of hematopoietic precursor cells. The disease usually accompanied by remarkable inflammatory and thrombotic disorders.
This case-control study aimed to measure levels of some inflammatory markers in serum from patients with PV.
The study recruited 30 patients with PV and other 30 age-and sex-matched familyunrelated healthy individuals. Blood samples were obtained from each participant, and levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and C-reactive protein (CRP) in the serum were evaluated.
PV patients showed significantly higher levels of IL-8 and CRP (71.13±11.4 pg/ml and 0.215 mg/L respectively) than controls (58.23±9.7pg/ml and 0.145 mg/L respectively. IL-6 levels did not show any significant variations between patients and controls (11.8±3.8 pg/ml vs 10.6±4.2 pg/ml).
The study indicates the importance of IL-8 and CRP as indicator for high levels of inflammatory events accompanied PV which may facilitate thrombotic events.
Polycythemia vera, C-reactive protein, IL-6, IL-8
