Placental alkaline phosphatase and total alkaline phosphatase as prognostic tests for abortion in pregnant women at second trimester

The present study was designed to evaluate the role of total alkaline phosphatase and placental alkaline phosphatase, in addition to another liver function tests in predicting abortion at second trimester of pregnancy. One hundred samples of blood were taken from pregnant women, The samples diagnosis done by ELISA system for demonstration about IgG, IgM antibody for abortion causes like Toxoplasmosis, CMV, Rubella, APL, ACL, in addition to measuring of total alkaline phosphatase and placental alkaline phosphatase as well as liver functions tests including (serum total protein, serum albumin, total serum bilirubine, direct and indirect bilirubine, gamma glutamyl transferase, glutamic oxalo acetic transaminase, glutamic pyruvic transaminase) according to kits manufactures. The results showed that there is a significant difference according to age group between the threatened abortion women as compared to normal pregnant women at second trimester. Statistical analysis showed significant increase in total, direct and indirect bilirubin concentration levels in threatened abortion women in second trimester as compared with normal pregnant women, Serum total protein concentration levels were showed no significant differences between normal pregnant and threatened abortion women during second trimester, while Serum concentration of albumin level was showed highly significant increase in threatened abortion women, as well as, GGT concentration also showed significantly increased level in threatened abortion women at second trimester when compared with normal pregnant women. Serum concentration level of ALT, AST, ALT/AST ratio were showed no significant differences between normal pregnant and threatened abortion during second trimester. Statistical analysis of TALP, PALP, PALP/TALP ratio were showed highly significant decrease mean serum level in threatened abortion women as compared with normal pregnant women at the same trimester.

Can be concluded that total alkaline phosphatase and Placental alkaline phosphatase concentration levels in case of threatened abortion women at second trimester in addition to their highly specificity and sensitivity may help the gynecologist in predicting abortion especially when these enzymes were estimated at the middle of second trimester (20 weeks of gestation), in addition to another liver function tests.