Indian Journal of Public Health Research & Development
  • Year: 2018
  • Volume: 9
  • Issue: 11

Correlation of hematological profile with CD4 counts in human immunodeficiency Virus-Positive patients in a rural area of South India

  • Author:
  • Abilash Sasidharananir Chandrakumari1,5,, Pammy Sinha2, Shreelakshmidevi Singaravelu3,5, S Jaikumar4
  • Total Page Count: 5
  • Page Number: 247 to 251

1Associate Professor, Department of Pathology, Shri Sathya Sai Medical College & Research Institute

2Professor & Head, Department of Pathology, Sri Lakshmi Narayana Institute of Medical Science Medical College & Hospital

3Associate Professor, Department of Pharmacology, Shri Sathya Sai Medical College & Research Institute

4Professor, Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Science Medical College & Hospital

5Research Scholar, Bharath Institute of Higher Education and Research, Chennai

*Corresponding Author: Dr. Abilash Sasidharananir Chandrakumari, Associate Professor Department of Pathology, Shri Sathya Sai Medical College & Research Institute Ammapettai, Nellikuppam, Tiruporur-Guduvancherry Main Road, Kancheepuram, Tamilnadu, India-603108 Phone: +919894346193, Email: abey4aris@gmail.com

Online published on 7 December, 2018.

Abstract

Hematological manifestations are routinely encountered in individuals infected with Human immunodeficiency virus (HIV). The Study is aimed at analysing the significance of haematological parameters in HIV-infected patients and to correlate with CD4+ counts.

The study was carried out over a period of two years and a total of 120 HIV positive patients were included. Patients were categorized into two groups, Group A include patients receiving Highly Active Anti-Retroviral Therapy (HAART) (n=68) & Group B include patients who were not on HAART (n=52). Hematological parameters inclusive of haemoglobin (Hb), total leukocyte count (TLC), differential count (DC), platelet count & CD4 counts were recorded.

Prevalence of anemia in our study was (67.5%). Morphologically normocytic normochromic (NCNC) anemia was the most common variant accounting for 50% in group A and 57.78% in group B. prevalence of leukopenia in our study population was 28.33% with a slightly higher prevalence in group B (42.31%) than group A (17.65%). Total number of patients with low CD4+ count was 46 (38.33%).

Anemia is the commonest hematological abnormality encountered throughout the stages of HIV infection. Prevalence of anemia is higher among patients who are not on HAART. Anemia and leukopenia can also serve as an excellent screening tool to assess the disease progression in HIV patients.

Keywords

HIV, Anemia, Leukopenia, HAART