Elderly immunity improvement after getting sinbiotic and zinc combinations

Elderly is one group of people who have a risk of changing immune function. Changes in immune function in the elderly, especially in the immune system mediated by cells. In accordance with the increase in age, the elderly immune system decreases the immune response against infectious and non-infectious diseases. Based on this, it is easy for the elderly to develop diseases such as infectious diseases, hypertension, coronary heart disease, cancer, autoimmune diseases, and other chronic diseases. The increasing number of elderly people is one indicator of the success of development as well as a challenge in development. The purpose of this study was to analyze the improvement of elderly immunity after getting synbiotics and zinc. The type of this research was an experimental study in which volunteers were given zinc + synbiotic combination supplements. Further measurements of IL-2, IFN-γ and IL-10 were carried out. Furthermore, the measurement results were compared to find out the differences in elderly immune expression. Analysis of normality and homogeneity to determine parametric or non-parametric statistical tests with the Shapiro-Wilk test if it meets parametric requirements then the analysis used in this study was t-test to evaluate the effect of supplementation (pre-post test). The results showed that synbiotic + zinc combination supplementation could potentially increase IL-2 profile (p = 0.000), IFN-γ (p = 0.019), and IL-10 (p = 0.010) significantly in the elderly. Based on the results, it could be concluded that synbiotic + zinc combination supplementation has the potential to increase IL-2, IFN-γ, and IL-10 profiles in the elderly.