Periodontal disease and CRP relatedness in korean adults

Healthy teeth and oral health are essential to keep health. With more attention to oral health in the ageing era, periodontal disease, the main factor which impedes oral health, draws more attraction. This study tries to observe an association between periodontal disease and C-reactive protein (CRP) in Korean adults, to reevaluate the importance and necessity of oral healthcare in national health promotion, and to provide the grounds for follow-up research.

From the raw data of the 6th 2015 National Health and Nutrition Examination Survey, 3, 760 samples that meet the conditions of this study were selected as study subjects. With the use of SPSS (ver 22.0), weight based complex sampling analysis was conducted with the study subjects. Depending on the prevalence of periodontal disease, average value analysis, Chi-square test and OR (95% CI) were compared in terms of CRP. To evaluate the influence of CRP periodontal disease on a rise in a CRP value (more than 1.0 mg/L), multinomial logistic regression analysis was conducted.

Regarding CRP distribution, less than 1.0 mg/L accounted for72.5%; more than 1.0 mg/L 27.5%; the average value (range) was 1.20 (0.09∼20.01) mg/L. The average value of CRP was 1.38 mg/L when there was the prevalence of periodontal disease, and was 1.13 mg/L where there wasn't periodontal disease (P=.010). The rate (%)of more than CRP 1.0 mg/L was significantly higher when there was the prevalence of periodontal disease than when there wasn't periodontal disease(OR (95% CI) = 1.57 (1.32∼1, 87), P<0.0001). According to the multinomial logistic regression analysis, after the correction of the study subjects’ characteristics, OR (95% CI) of high CRP (more than 1.0 mg/L) was1.26 (1.04∼1.53) when there was the prevalence of periodontal disease. The prevalence of periodontal disease significantly influenced a rise in a CRP value (P=.020).

When there was periodontal disease, a CRP value increased. Periodontal disease is a typical oral disease which is not treated carefully despite its high prevalence rate. A rise in a CRP value can influence systemic health. Therefore, it is necessary to enhance the importance of periodontal disease care not only for oral health, but for systemic health promotion. It is urgent to come up with an active plan of periodontal disease care for the whole nation. In addition, it is required to develop a practical support program and activate relevant research.