Indian Journal of Public Health Research & Development
  • Year: 2018
  • Volume: 9
  • Issue: 11

Association of mir-499 gene polymorphism with some hormones in type 2 diabetes mellitus patients

  • Author:
  • Israa Harjan Mohsen1, Haider Kamil Zaidan2, Ishtar Munim Nassir3, Ali Hmood Al-Saadi1, Mona N. Al-Terehi1, Methaq J. Al-Jboori4
  • Total Page Count: 5
  • Page Number: 1921 to 1925

1College of Sciences/University of Babylon/Iraq

2Embassy of the republic of Iraq cultural Attaché/Amman/Jordan

3Babylon Health Directorate/Iraq

4College of Science-Al-Mustansiriyah University/Iraq

Online published on 7 December, 2018.

Abstract

The genetic analysis of PCR-RFLP technique determined the genotype of miR-499gene, which found that the homozygote (AA) pattern was significantly higher in patients than in control group. On the other hand, the statistical analysis for the role of microRNAs genes in the hormones and physiological parameters above found that thehomozygote (AA) pattern of miR-499gene show more effects in changes of parameters (cortisol, testosterone, estradiol, insulin, glucagon, Fasting Blood Glucose (FBG), insulin resistance, insulin sensitivity, microalbuminuria systolic and diastolic pressure).

polymorphisms in miR-499 mediated diabetic cardiomyopathy.

Keywords

T2DM, microRNA, miR-499, Polymorphism, RFLP technique, agarose-gel electrophoresis