1Associate Professor, Department of Oral Medicine and Radiology, S.C.B. Dental College & Hospital, Cuttack, India
2Principal, S.C.B. Dental College & Hospital, Cuttack, India
3Assistant Surgeon, C.H.C., Sarkipalie, Bargarh, Odisha, India
4Associate Professor, Department of Oral Pathology & Microbiology, I.D.S., Siksha “O” Anusandhan, Deemed to be University, BBSR, Odisha, India
5Post graduate Student, Department of Oral Medicine and Radiology, S.C.B. Dental College and Hospital, Cuttack, Odisha, India
6Professor, Department of Otorhinolaryngology, IMS and SUM Hospital, Siksha “O” Anusandhan, Deemed to be University, Kalinganagar, Bhubaneswar, Odisha, India
7Assistant Professor, Department of Medical Research Laboratory, IMS and SUM Hospital, Siksha “O” Anusandhan, Deemed to be University, Kalinganagar, Bhubaneswar, Odisha, India
Online published on 13 December, 2018.
Photodynamic therapy (PDT) is a contemporary and non-invasive therapeutic approach, used in the treatment of non-oncological diseases as well as cancers. The present study was conducted to evaluate the efficacy of 5-aminolevlinic acid-mediated PDT (5-ALA-PDT) as an alternative therapeutic modality for oral lichen planus (OLP) as well as its role in OLP calcitrant to conventional pharmacologic treatments.
This study was based on the premise of non-randomized, non-comparative prospective split mouth design. The study sample of 36 patients was selected from the patients attending the Outpatient Department of Oral Medicine and Radiology, SCBDCH based on predefined inclusion and exclusion determinants. Objective (REU score) and subjective symptom assessment (VAS score) was done at baseline and at 2 weeks, 4 weeks and 3 months follow up post 5-ALA mediated PDT.
Statistically significant intra group difference was observed in REU and VAS score (p=0.000) was observed. Statistically significant results were obtained for VAS at 4 weeks (p=0.000) and 3 months (p=0.000) and at 3 months (p=0.008) for REU.
This study shows promising results favoring the use of PDT for oral lichen planus, both as a curative and palliative measure. Effectiveness of multimodal approach combining PDT with conventional treatment is a potential ground for future research.
Photodynamic Therapy, Lichen Planus, Amino Levulinic Acid
