1Lecturer, Dept of Oral Pathology & Microbiology, Hi Tech Dental College & Hospital, BBSR, Odisha
2Associate Professor, Dept of Oral Pathology & Microbiology, Institute of Dental Science, BBSR, Odisha
3Associate Professor, Dept of Oral Medicine & Radiology, SCB Dental College & Hospital, Cuttack, Odisha
4Professor, Department of Otorhinolaryngology, IMS and SUM hospital, Siksha “O” Anusandhan, Deemed to be University, K8, Kalinganagar, Bhubaneswar, Odisha, India
5Assistant Professor, Department of Medical Research Laboratory, IMS and SUM hospital, Siksha “O” Anusandhan, Deemed to be University, K8, Kalinganagar, Bhubaneswar, Odisha, India
6Professor, Deaprtment of Prosthodontia, C.D.C.R.I., Rajnandgaon, Chhattisgarh, India
7Tutor, Dept of Oral Pathology & Microbiology, Institute of Dental Science, BBSR, Odisha
*Corresponding author: Dr. Saswati Siddhartha Lecturer, Dept of Oral Pathology & Microbiology, Hi Tech Dental College & hospital, BBSR, Odisha. Email- saswati20@gmail.com
Online published on 13 December, 2018.
GLUT-1 is an endogenous marker of hypoxia which has been identified in diverse human tumors and there is evidence that GLUT-1 is associated with tumor aggressiveness in head and neck squamous cell carcinoma.
Evaluation and comparison of GLUT-1 expression in verrucous carcinoma & various grades of squamous cell carcinoma.
Our study aims to find the correlation of GLUT-1expression with the clinical and histopathological features of various lesions included in the study which are Verrucous carcinoma and various grades of squamous cell carcinoma. It also aims at evaluating the aggressiveness of each individual lesion.
Study group-Histopathologically diagnosed 10 verrucous carcinoma(VC) cases, 30 oral squamous cell carcinoma (OSCC) cases, 10 each of well differentiated, moderately differentiated and poorly differentiated were selected. Only primary carcinoma cases were considered. For control group-10 biopsy specimen of normal oral mucosa that are taken during minor oral surgical procedures with patient consent. Immunohistochemisrty method was employed to evaluate the GLUT-1 expression in the various tissue sections.
GLUT-1expression is increased VC and OSCC in comparison to normal mucosa. Its expression in various OSCC cases is correlated with the aggressiveness, local metastasis.
Immunoexpression of GLUT-1 of tumor cells (VC & OSCC) can act as an adjunct in predicting the aggressiveness of each lesion and better prognosis can be achieved by modified treatment planning as per the need of the individual lesion.
Glut-1, Squamous cell Carcinoma, Verrucous Carcinoma
