1Associate Professor, Department of Oral Medicine and Radiology, S.C.B. Dental College & Hospital, Cuttack, India
2Principal, S.C.B. Dental College & Hospital, Cuttack, India
3Assistant surgeon, C.H.C., Sarkipalie, Bargarh, Odisha, India
4Associate Professor, Department of Oral Pathology & Microbiology, I.D.S., Siksha “O” Anusandhan, Deemed to be university, BBSR, Odisha, India
5Post graduate student, Department of Oral Medicine and radiology, S.C.B. Dental College and Hospital, Cuttack, Odisha, India
6Professor, Department of Otorhinolaryngology, IMS and SUM hospital, Siksha “O” Anusandhan, Deemed to be University, Kalinganagar, Bhubaneswar, Odisha, India
7Assistant professor, Department of Medical Research Laboratory, IMS and SUM hospital, Siksha “O” Anusandhan, Deemed to be University, Kalinganagar, Bhubaneswar, Odisha, India
*Corresponding author: Dr. Fakir Mohan Debta, Associate Professor, Department of Oral Medicine and Radiology, S.C.B. Dental College & Hospital, Cuttack, India. Email- fm_debta@rediffmail.com
Online published on 13 December, 2018.
Methylene blue, widely used as a histologic dye, has potential photochemical and photobiological properties favoring its use as a photosensitiser in photodynamic therapy (PDT) of varied diseases. This study was designed to assess the efficacy of MB mediated PDT in treatment of Oral Lichen Planus.
A sample selection of 37 patients was done based upon a predefined set of inclusion and exclusion determinants from the Outpatient Department of Oral Medicine and Radiology, SCBDCH, Cuttack This study encompassed a non-randomized, non-comparative prospective split mouth study protocol. Pre-treatment assessment of clinical presentation and symptoms was done using REU and VAS score respectively. The subjects were treated with a single session of MB-PDT and followed up after 2 weeks, 1 month and 3 months from baseline. The post treatment REU and VAS recorded at each visit for the test and control site separately.
For the final sample of 35 recruits, Repeated measure ANOVA was used for analysis of REU and VAS score among various visits in test group. With respect to REU scores, statistically significant results were obtained for baseline with 3 months follow up, for 2 weeks with 3 months follow up and for 4 weeks with 3 months follow up. The VAS score was statistically significant amongst all comparisons.
MB is photochemically and photobiologically a dynamic molecule which can be effectively harnessed to target various premalignant and malignant pathologies to prevent its progression.
Methylene blue, Photodynamic therapy, REU score
