Indian Journal of Public Health Research & Development
  • Year: 2018
  • Volume: 9
  • Issue: 12

The relationship between hypermobility syndrome and systemic lupus erythematosus

  • Author:
  • Mohammed H. Al-Osami1, Sarah Mohammed2, Waleed Ibraheem Ali3, Hayder Adnan Fawzi4,
  • Total Page Count: 7
  • Page Number: 526 to 532

1Assistant Professor, College of Medicine, University of Baghdad, Baghdad, Iraq

2Baghdad Teaching Hospital, Ministry of Health, Baghdad, Iraq

3Instructor Lecturers in Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq

4Baghdad Teaching Hospital, Ministry of Health, Clinical Pharmacy Department, Baghdad, Iraq

*Corresponding author: Hayder Adnan Fawzi Baghdad Teaching Hospital, Clinical Pharmacy Department, Ministry of Health, Baghdad, Iraq Email: hayder.adnan2010@gmail.com

Online published on 9 January, 2019.

Abstract

investigate joint laxity in patients with systemic lupus erythematosus (SLE).

Case-control study involved 53 patients with SLE; disease activity for SLE assessed with the SLE Disease Activity Index (SLEDAI). Case histories and personal information assessed: age, SLE disease duration, body mass index (BMI), all subjects screened for hypermobility syndrome according to criteria of Beighton for joint hypermobility (total score 4 or more).

Twenty-eight (52.8%) of the patients SLE had hypermobility compared to 31 (47.7%) of the control group. There is a slight increase in the risk of hypermobility in SLE patients compared to control the OR (95%CI): 1.229 (0.594–2.540). Considering joints complain Elbow pain was significantly higher in SLE patients compared to control. However, the rest (back, knee, and shoulder) showed no statistical difference between SLE and control. In SLE patients lower BMI associated significantly with hypermobility. There was a weak inverse relationship between hypermobility and age. There was no significant association in systemic lupus erythematosus patients between hypermobility with Anti-dsDNA, ANA, C3 and C4, but longer duration of disease and higher disease activity (SLEDI) associated weakly with hypermobility.

SLE patients had a similar probability of having hypermobility compared to control, hypermobility increase with increasing immunological markers and with lower age and BMI, disease activity and ESR weakly increase the risk of hypermobility in SLE patients. Elbow joint pain associated with hypermobility in SLE compared to control while no such relationship found with back, knee and shoulder pain.

Keywords

SLE, Hypermobility, disease activity index, joint pain, disease activity