Indian Journal of Public Health Research & Development
  • Year: 2018
  • Volume: 9
  • Issue: 12

Association of apolipoprotein e polymorphism with cognitive functions in elderly

  • Author:
  • N. Saelan Tadjudin1, Andi Jayalangkara Tanra2, Andi Asadul Islam3, Suryani As'ad4, Muh. Nasrum Massi5, Ilhamjaya Patellongi6, Prihantono Prihantono3
  • Total Page Count: 6
  • Page Number: 711 to 716

1Department of Psychiatry, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia

2Department of Psychiatry, Hasanuddin University, Makassar, Indonesia

3Department of Surgery, Hasanuddin University, Makassar, Indonesia

4Department of Nutrition, Hasanuddin University, Makassar, Indonesia

5Department of Microbiology, Hasanuddin University, Makassar, Indonesia

6Department of Physiology; Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Online published on 9 January, 2019.

Abstract

This study aims to examine the association between apolipoprotein E polymorphism (APOE) and cognitive functions test using Montreal Cognitive Assesment-Indonesian version 2012 (MoCA-Ina) in elderly.

A cross-sectional study of 112 elderly participants from two nursing homes in Jakarta. APOE gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

There are four genotypes: E2/E2 10(8.9%), E3/E3 38(33.9%), E3/E4 46(41.1%) and E4/E4 18(16.1%). The percentage of E2 allele 20(8.9%), E3 122(54.5%), E4 82(36.6%). The cognitive function test, MoCA-Ina ≥ 26: 34(40%) participants with genotype E2/E2 3(8.8%), E3/E3 7(20.6%), E3/E4 16(47.1%) and E4/E4 8(23.5%). MoCA-Ina < 26: 51(60%) 51 participants with genotype E2/E2 7(13.7%), E3/E3 14(27.5%), E3/E4 22(43.1%) and E4/E4 8(15.7%). A significant relationship between APOE gene polymorphism with MoCA-Ina-abstraction: E3/E4 vs. E3/E3 p 0.019, E4/E4 vs. E3/E3 p = 0.028, a significant relationship between APOE gene polymorphism with MoCA-Ina-language: E3/E4 vs. E2/E2 p = 0.03, E4/E4 vs. E2/E2 p 0.029, and a significant relationship between APOE gene polymorphism with naming: E3/E4 vs. E2/E2 p = 0.048.

High percentage of APOE allele E4 may be one of the causes of high cognitive function decline. APOE gene polymorphisms associated with the decreased cognitive function; abstraction, language, and naming. Allele E4 may be a potential factor for cognitive function decline.

Keywords

MoCA-Ina, Elderly, polymorphism, APOE, gene