1Department of Chemistry, College of Science, Mustansiriyah University, Baghdad
2Department of Biology, College of Science, Mustansiriyah University, Baghdad
*Corresponding author: Mohammed F. Al-Marjani Department of Biology, College of Science, Mustansiriyah University, Baghdad E-mail: dr.marjani@uomustansiriyah.edu.iq.
Online published on 2 February, 2019.
New compound was synthesized with good yields using simple methodology. 1, 3 oxazole have been synthesized and evaluated anti-bacterial activity for some them. all derivatives were synthesized from hippuric acid (A1) was obtained by the reaction of glucine with benzoyl chloride. oxazole derivatives (A2-A9) was obtained by the reaction of acetic anhydride with acetic acid then to get (A10-A17) react with ethylene di amine that compound was closs, or get(A18-A26) react with ethylene di amine less hours number, then prouduct react with chloro acetyl chloride (A26-A33). The product compounds were characterized by FTIR and 1HNMR spectra. The results enhanced the activity of new compounds as promising antimicrobial agents and the compound had highly effect against Staphylococcus aureus in treatment skin infection (in vivo) when the healing was occur after fve days compare with control.
Oxazole, imidazole derivatives
