Indian Journal of Public Health Research & Development

  • Year: 2018
  • Volume: 9
  • Issue: 12

Immunohistochemical Expression of CDX2 Protein in Iraqi Patients with Human Gastric Cancer (HGC)

  • Author:
  • Hanan Jameel Ashour1,, Nahla A. Al-Bakri1, Kifah Hamdan Abdul-Ghafour2
  • Total Page Count: 6
  • Page Number: 1148 to 1153

1Department of Biology, College of Education for Pure Science (Ibn-AL-Haitham), University of Baghdad, Iraq

2Department of Pathology, College of Medicine. University of Baghdad, Iraq

*Corresponding author: Hanan Jameel Ashour Department of Biology, College of Education for Pure Science (Ibn-AL-Haitham), University of Baghdad, Iraq

Online published on 2 February, 2019.

Abstract

This study aimed to evaluate the IHC expression of CDX2 protein in HGC patients and control groups and also to study the correlation between IHC expression of the CDX2 and different clinicopathological variables such as: age, gender, histopathological subtype, grade, and stage of the tumor in HGC cases. the retrospectively sectional study for the period from 2014 to 2018 included a total of 60 formalin fxed paraffn embedded blocks of the HGC tissue (partial or total gastrectomy specimens) that collected from the archived materials of the Department of Pathology of Baghdad Teaching Hospital and the Center of Gastrointestinal and Hepatic Diseases, and also some samples were collected from other private laboratories. The IHC expression of the CDX2 was signifcantly increased in HGC group compared with control groups (p<0.0001). A clinic-pathological assessment revealed that patient's samples involved 20 males and 10 females; Male to female ratio was 2: 1. The age of patients was ranged between 18–76 years with a mean ± standard error of (48.39±12.39) year. The majority of the HGC cases, in this study (53.3%) were above 48 years of age. the commonest histopathological subtype was the diffuse subtype (46.6%).

Keywords

CDX2, HGC, IHC expression