1Departmen of Epidemiology, Public Health, Mandala Waluya, Indonesia
2Departmen of Nutrition, Medicine, Mandala Waluya, Indonesia
3Department of Pharmacy, Mandala Waluya, Indonesia
4Department of Public Health, Postgraduate Program, Mandala Waluya, Indonesia
5Midwifery Department Graduate School of Hasanuddin Univeristy, Makassar, Indonesia
*Corresponding: Andi Nilawati Usman, Jalan Goa Ria, Villa Pelita Asri 18, Makassar, 90245, Indonesia, Mobile Phone: +6285255990153
Online published on 2 February, 2019.
Rheumatoid arthritis is an autoimmune disease and need the balancing of immune system. Foxp3 Treg level is one of critical regulator to balance system immune. This study aim to analyze potential of propolis and honey propolis for prevention rheumatoid arthritis based on Foxp3 Treg as a target.
It was a quasi-experimental study with pretest-posttest control design, Subject divided into 3 groups, group 1 control did not give anything, group2 given propolis 60 mg/capsule and group 3 given honey propolis 35 mg/pack. Propolis and Honey Propolis Trigona was giving through 14 days and blood sample for ELISA examination taken three times, Before intervention (baseline), 7 day after intervention and 14 days after intervention.
Analysis mean difference between baseline data with 14 days data show giving honey propolis has the highest increase of Foxp3 Treg and giving propolis has the lowest increase of Foxp3 Treg. Among the three groups, only the group given honey propolis has a signifcant effect.
Honey propolis has potential effect as therapy for prevention arthritis rheumatoid by increase Foxp3 Treg level. Adherence to consume honey propolis is necessary to provide the maximum effect.
Honey Propolis, Trigona, Arthritis Rheumatoid, Autoimmune
