1Clinical Researcher, Orchids Breast Health Clinic, Prashanti Cancer Care Mission, Senapati Bapat Road, Pune, India
2Student, Orchids Breast Health Clinic, Prashanti Cancer Care Mission, Senapati Bapat Road, Pune, India
3Clinical Research Scientist, Orchids Breast Health Clinic, Prashanti Cancer Care Mission, Senapati Bapat Road, Pune, India
4Radiologist, Orchids Breast Health Clinic, Prashanti Cancer Care Mission, Senapati Bapat Road, Pune, India
5Sr. Radiologist, Orchids Breast Health Clinic, Prashanti Cancer Care Mission, Senapati Bapat Road, Pune, India
6Research Scientist, Orchids Breast Health Clinic, Prashanti Cancer Care Mission, Senapati Bapat Road, Pune, India
7Research Coordinator, Orchids Breast Health Clinic, Prashanti Cancer Care Mission, Senapati Bapat Road, Pune, India
8Medical Oncologist, Orchids Breast Health Clinic, Prashanti Cancer Care Mission, Senapati Bapat Road, Pune, India
9Physician, Orchids Breast Health Clinic, Prashanti Cancer Care Mission, Senapati Bapat Road, Pune, India
Online published on 16 March, 2018.
Current Breast Cancer (BC) knowledge has primarily emerged from translational research in western populations. Given the genomic and population diversity, mere extrapolation of this knowledge to BC in Indian women is incorrect. Hence, Indian-population specific research resources are needed1. Herein, we describe the creation of a pilot BC BioBank as a repository of clinically annotated biospecimens from BC patients at our clinic.
to establish a BC Biobank for collaborative translational research
Given its high prevalence in India, our pilot study focuses on a BC subtype named triple Negative BC (TNBC). Retrospective data (i.e., medical history, clinico-pathology, imaging, surgery, chemotherapy and post-treatment status etc.) was collected after informed consent from TNBC patients. Formalin-fixed paraffin-embedded (FFPE) tissue from post-surgery samples was also collected. In addition, Radiology images of TNBC were analyzed to identify unique imaging characteristics.
Out of 115 registered TNBC cases at our clinic, a pilot BioBank was generated with clinical data and FFPE blocks of 44 samples. Clinico-pathology details and medical history were meticulously collected for this study cohort. From these cases, extensive radiology imaging analysis was performed on 25 cases to identify unique Mammography or SonoMammography features of TNBC in Indian women.
The DNA from FFPE blocks of TNBC tumors is being used to identify mutational patterns in cancer-specific genes. The TNBC Imaging database has generated collaborations with imaging scientists to identify unique radiological features of Indian TNBCs.
In this project, we have created a novel research repository for TNBC-themed research in Indian women. this unique project is acting as a driver for multidisciplinary research collaborations with scientists from academic and private sectors.
Biobank, Triple Negative Breast Cancer, Translational Research
