1Junior Resident, Department of Pathology, S.M.S.&R
2Assistant Professor, Department of Pathology, S.M.S. &R, Greater Noida
3Associate Professor, Department of Pathology, S.M.S. &R, Greater Noida
4Professor, Department of Pathology, S.M.S. &R, Greater Noida
Prostate cancer is one of the common malignancy in males in India. Prostate Specific Antigen (PSA) is currently the best screening modality available for the detection of prostrate carcinoma.
To determine the correlation of total PSA levels in different Prostatic lesions.
This prospective analytical study was conducted over a period of one year (June 2015 to May2016) in the department of Pathology, SMS&R Greater Noida. Total PSA estimation was done in all prostratic lesions immunometrically on Vitros ECi system.
All cases of adenocarcinoma showed total PSA ranging from 54.1–94.1 ng/ml except one which exhibited normal level of PSA of 5.6 ng/ml. There was one case of urothelial carcinoma which showed low serum PSA level of 2.4 ng/ml. In HGPIN total PSA level ranged from 45.4–58.6 ng/ml while in LG PIN PSA varied from 9.2–17.1 ng/ml. In non-neoplastic lesions it ranged from 3.76–6.62 ng/ml and it showed increase with an increase age.
The total PSA level of more than 54 ng/ml is highly suggestive of malignancy while 45–50 ng/ml were suggestive of HGPIN. Such cases should be thoroughly searched for malignancy.
prostate specific antigen, prostate cancer, screening, immunometric assay
