Indian Journal of Public Health Research & Development
  • Year: 2018
  • Volume: 9
  • Issue: 3

Analysis of Methanolic extract of Secondary Metabolites Released by Candida glabratus using GC-MS and Evaluation of Its Antimicrobial Activity

1College of Pharmacy

2Department of Biology, College of Science for Women, University of Babylon, Hillah City, Iraq

3Biomedical Science Department, University of Babylon, College of Nursing, Hillah City, Iraq

*Corresponding author: Imad Hadi Hameed Biomedical Science Department, University of Babylon, College of Nursing, Hillah city, Iraq; Phone number: Mob.: 009647716150716; E-mail: imad_dna@yahoo.com

Online published on 3 April, 2018.

Abstract

The objectives of this study were analysis of the secondary metabolite products and evaluation antibacterial and antifungal activity. Bioactives are chemical compounds often referred to as secondary metabolites. Thirty nine bioactive compounds were identified in the methanolic extract of Candida glabratus. The identification of bioactive chemical compounds is based on the peak area, retention time molecular weight and molecular formula. Coriandrum sativum was very highly antifungal activity (6.80±0.25)mm. The results of anti-fungal and anti-bacterial activity produced by Candida glabratus showed that the volatile compounds were highly effective to suppress the growth of Penicillium expansum (5.95±0.20) and Escherichia coli (5.900±0.22).

Keywords

Candida glabratus, GC-MS, Antifungal and Antibacterial, Secondary metabolites