1Senior Lecturer, Dr. D.Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Sant Tukaramnagar, Pimpri, Pune, Maharashtra, India
2Reader, Dr. D.Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Sant Tukaramnagar, Pimpri, Pune, Maharashtra, India
3M.D.S. II, Dr. D.Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Sant Tukaramnagar, Pimpri, Pune, Maharashtra, India
4Professor, Dr. D.Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Sant Tukaramnagar, Pimpri, Pune, Maharashtra, India
*Corresponding author Dr. Anjali P Ganjre, Senior Lecturer, Dr. D.Y. Patil Dental College and Hospital, Dr D.Y. Patil Vidyapeeth, Sant Tukaramnagar, Pimpri, Pune-18. Maharashtra, India. Phone No-9970722995, E-mail: dr_apg1@yahoo.co.in, dranjpg@gmail.com
Online published on 29 May, 2018.
Tobacco smoke (TS) causes over-expression of multiple genes involved in metabolism of carcinogens in oral epithelium. TS are of 2 types active and passive. According to a newer concept, third hand smoke (THS) is a form of residual tobacco smoke pollutants after the emission of tobacco smoke and remains on the surface for weeks and months together after cessation of smoking. We have earlier hypothesized that when oral mucosa of non-smoker person comes in continuous contact with THS, it could lead to oral cancer. Stem cells share similar attributes as of cancer stem cell. Evaluation of role of oral stem cells in carcinogenesis process is critical. Thus, for the first time, we would like to hypothesize that assessing oral stem cells could provide a good source to evaluate the role of THS in carcinogenesis and hence can act as a biomarker for the same.
Carcinogens, oral stem cells, tobacco-smoke
