Characterization of Metabolites Produced by Shegilla dysenteriae and Determination of Its Anti-Fungal Activity

Shigella species generally invade the epithelial lining of the colon, causing severe inflammation and death of the cells lining the colon. This inflammation results in the diarrhea and even dysentery that are the hallmarks of Shigella infection. The aims of our research were analysis of the secondary metabolite products and evaluation antifungal activity. Forty bioactive compounds were identified in the methanolic extract of Shegilla dysenteriae. GC-MS analysis of Shegilla dysenteriae revealed the existence of the 1-Deoxy-d-mannitol, γ-Thionodecalactone, Hexaborane, 1-Propanamine, 3-(methylthio), 1H-Pyrrole, 1-pentyl, 2-Propanone, 1-(N-cyanomethylimino-), 1-Pentanol, 5-methoxy, 2-Methyl-4-methoxy-1-butanol, Benzeneethanamine, 2-Butanamine, (S), L-valine, N-glycyl, N-carbobenzyloxy-l-tyrosyl-l-valine, DL-Isoleucine, and 3-Buten-2-one, 4-(dimethylamino)-3-[(1-methylethyl). Daucus carota was very highly active (6.953±0.22) mm. The results of anti-fungal activity produced by Shegilla dysenteriae showed that the volatile compounds were highly effective to suppress the growth of Aspergillus flavus (6.00±0.22). Based on the significance of employing bioactive compounds in pharmacy to produce drugs for the treatment of many diseases, the purification of compounds produced by Shegilla dysenteriae can be useful.