1Health Polytechnic Ministry of Health, Semarang, Indonesia
2College of Business Administration and Port Management Barunawati, Surabaya, Indonesia
*Corresponding Author: Diyah Fatmasari Health Polytechnic Ministry of Health, Semarang, Indonesia
Online published on 25 September, 2018.
Fluoride reduces dental caries by creating the fluor apatite which is more invulnerable to acid caries attack. However, the conventional fluoride found in toothpaste is seldom to reach the therapeutic achievement level when interacting with water during teeth brushing. As such fluoride in a systemic mode without passing metabolism with safe dose needs developing through transdermal drug delivery. This study aims to investigate the compatibility of Sodium Fluoride (Na F) patch as the transporter of fluoride to prevent caries attack besides the viability of macrophage cell and haemolytic acute to secure safety.
This research applied experimental clinical laboratories with pre and post control group design. The sample of the acute haemolytic test was performed with a physiologic saline solution and oxalate blood. The sample of viability was the suspension of macrophage cell on a trifan blue solution. Furthermore, the irritation skin test was tested on five rabbits attached Na F patch on the left back side while the one as the control group was attached a patch without Na F on the right side.
There were no differences of erythrocyte lysis and macrophage viable between the group of Na F patch and without Na F patch. Skin irritation test was shown on Mann Whitney result the significance of 0.317 indicating no differences of skin reaction between rabbit back which was applied with Na F patch and not attached.
Na F patch has excellent biocompatibility and safe to be used.
Na F patch, biocompatibility, haemolytic, irritation, rabbits
