Histopathological comparison of brain injury after treatment of stem cell

Our experiment studied that grafted stem cells reduced behavioral deficiency in rodent animal models of focal ischemia..

The cerebral injuries were produced by middle cerebral artery occlusion (MCAO). The transplants were made on the seventh day after the injuries. Transplanted cells were labeled with cell marker CM-Dil. The infarction area was treated with TTC staining & fluorescent dye..

Our research proved the effect of embryonic stem cells to the cerebral infarction caused by middle cerebral artery occlusion, focusing the application of grafted stem cells for reduction of infarction and regeneration of nervous injury. Our research suggests manifest results that implantation of mouse embryonic stem cell could show behavioral improvement after severe cerebral damage. The injury areas of infarction volumes show smaller in the transplant group than the volume of the non-transplant group..

Stem cell implant therapy may enhance the effectiveness of stem cell implant for central nervous system injury. Therefore, mouse embryonic stem cell (mESC) could be useful application for the method in neurological injury. Our studies suggest that the transplant of mESC may be used for the treatment of brain injuries.