1College of Korean Medicine, Semyung University, Jecheon, 27136, KS001, Republic of Korea
*Corresponding Author: Nayoung Jo Professor Division of Acupuncture & Moxibustion Medicine, Semyung University, Korea Email: cswcny2@hanmail.net
Online published on 16 October, 2018.
The intention of this study was to verify anti-fatigue and anti-inflammatory effects of tip and upper sections of velvet antler (VA) in mice and cells..
VA was divided into tip (VA-Tip) and upper (VA-Upper) sections. Forced swimming test was performed to examine the effect on muscle endurance improving and blood lactic acid reducing in ICR mice. In addition, nitric oxide (NO), inducible nitric-oxide synthase gene (iNOS) and cyclooxygenase-2 gene (COX-2) levels were examined in RAW 264.7 cells..
In the forced swimming test, the effect of the velvet antler was seen in the increased swimming times. VA-Tip group swam for approximately 320% longer as compared to the saline group (p<0.001). Blood lactic acid levels in VA-Upper group demonstrated a significant reduce in comparison with the control group (p<0.05). Because of treatment of VA extracts, nitric oxide production was significantly decreased and iNOS and COX-2 gene expressions were also inhibited significantly in LPS-effectuated RAW 264.7 cells..
Velvet antler extracts, not only tip section but also upper section, may have anti-fatigue and anti-inflammatory effect.
Velvet antler(VA), Fatigue, Endurance, Lactic acid, NO
