1Assistant Professor, Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli
2Associate Professor, Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli
3Professor, Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli
4Junior Resident, Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli
*Corresponding Author: Email: vaishnavilab@rediffmail.com
Online published on 10 October, 2016.
Pancytopenia is reduction in all three major formed elements of blood: erythrocytes, leucocytes and platelets. It has been observed in Indian scenario that megaloblastosis-Vit. B 12 and folate deficiency is the commonest cause of pancytopenia. However, the frequency with which each condition is associated with pancytopenia differs considerably depending upon various factors including geographic distribution.
1. To study the frequency of pancytopenia in patients admitted in tertiary hospital. 2. To correlate the clinical findings, haemogram, bone marrow aspirate and/or bone marrow trephine biopsy.
This retrospective study was carried out over a period of three years in the department of pathology at tertiary hospital from Jan 2012 to Dec.2015. In this period, a total of 60 bone marrow examinations that fulfilled the criteria for pancytopenia were studied.
Total 60 cases were studied in the given period. The most common cause of pancytopenia was Megaloblastic anemia followed by aplastic/Hypoplastic anemia. Commonest age group of presentation of pancytopenia was between 21–30 years, male to female ratio being 0.9: 1. Pallor was the most common clinical feature.
Among the conditions that causes Megaloblastic anemia due to Vit. B12/Folate deficiency, i.e. nutritional in origin seems to reflect the higher prevalence of pancytopenia in Indian subjects-which is easily reversible.
Pancytopenia, bone marrow examination, megaloblastic anemia, iron stores, Aplastic anemia, vitamin B12
