Giant Plexiform Unicystic Ameloblastoma: A rare variant of Ameloblastoma

Ameloblastoma is the most common clinically significant odontogenic tumor of the gnathic bones, characterized as a benign but persistent and locally aggressive neoplasm. According to the WHO, it presents in four forms: unicystic, multicystic, peripheral (within soft tissue), and desmoplastic, with the conventional solid intra-osseous type being the most common (86%). Microscopically, many subtypes or patterns have been described: follicular, plexiform, acanthomatous, papilliferous-keratotic (including so-called keratoameloblastoma), granular cell, desmoplastic, vascular, and with dentinoid induction (dentinoameloblastoma). This report describes a case of a giant unicystic ameloblastoma involving the left side of the mandible. Radiographically appearing as a unilocular radiolucency and non-dentigerous in nature. Histopathological analysis showed features of plexiform pattern of a unicystic ameloblastoma.