Indian Journal of Pathology and Oncology
  • Year: 2016
  • Volume: 3
  • Issue: 4

EDTA dependent pseudothrombocytopenia-cause and incidence

1UG Student, Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli

2PG Student, Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli

3Professor, Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli

4Professor & Head, Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli

*Corresponding Author: Email: yashkale33@gmail.com

Online published on 23 June, 2017.

Abstract

To find out the incidence of EDTA dependent pseudothrombocytopenia(PTCP)

To confirm EDTA dependent pseudothrombocytopaenia(PTCP) by counting the platelets using anticoagulants other than EDTA (citrate and heparin)

Pseudothrombocytopenia (PTCP) meaning there by a spuriously low platelet count.

EDTA induced clumping of platelets is one of the important cause of pseudothrombocytopaenia.

Inclusion criteria: All 3000 blood samples received during study period in hematology laboratory of BVDU Medical college sangli for complete blood count (CBC) or platelet count

Exclusion criteria:

1. Patients with known cause of thrombocytopenia were excluded.

2. Thrombocytopenia due to technical errors.

The incidence of EDTA Dependent Pseudothrombocytopenia was 0.13%.

The incidence of EDTA dependent Pseudothrombocytopenia is quite low.

Every sample with a low platelet count with EDTA as anticoagulant and/or presence of platelet clumps on the peripheral blood smear, and after ruling out other causes of pseudothrombocytopenia, must be collected again in a vaccutainer containing different anticoagulant (heparin and citrate). If the platelet count rises therein, it should be considered as a case of EDTA dependent Pseudothrombocytopenia.

Keywords

Platelet count, Pseudothrombocytopenia, EDTA dependent Pseudothrombocytopenia