1Associate Professor, Dept. of Pathology, Dr. B. R. Ambedkar Medical College Bangalore, Karnataka
2Associate Professor, Dept. of Pathology, D. Y. Patil Medical College, Kolhapur, Maharashtra, India
3PG Student, Dept. of Pathology, Dr. B. R. Ambedkar Medical College Bangalore, Karnataka
4PG Student, Dept. of Pathology, Dr. B. R. Ambedkar Medical College Bangalore, Karnataka
5Professor & HOD, Dept. of Pathology, Dr. B. R. Ambedkar Medical College Bangalore, Karnataka
*Corresponding Author: Email: dranu77@gmail.com
Online published on 27 November, 2018.
Gallstone disease is a major health problem and puts notable burden on individuals and health care system worldwide. This research was carried out to study the varied histopathological changes in the gallbladder mucosa as a result of cholelithiasis.
The present research comprised 190 gallbladder specimens obtained from cholecystectomy procedures conducted at tertiary teaching hospital in Bangalore. The gross examination was done after fixing the specimens with 10% formalin. Haematoxylin and eosin was used to stain gallbladder sections from fundus, body and neck.
On gross examination, congestion was noticed on surface of gall bladder in 67 cases (35.26%), wall was thickened in more than half of cases 104 (54.74%). Nearly a quarter of specimens showed pathological changes in mucosa of gallbladder (23.15%). Histopathological examination observed evident epithelial hyperplasia in 80 cases (42.1%), antral metaplasia in 20 (10.5%), intestinal metaplasia in 12 (6.3%), dysplasia with carcinoma in one case (0.53%).
Gallstones produce a wide range of histopathological changes in mucosa and calls for dedicated attention of pathologist routinely.
Cholelithiasis, Dysplasia, Hyperplasia, Metaplasia
