1Postgraduate Program, Hasanuddin University
2BBLK Makassar, Sulawesi Selatan
Online published on 5 November, 2018.
Testicular torsion will lead an ischemic process, that will reduce germinal cells, Sertoli cells and eventually Leydig cells. The disfunctional Sertoli cells will destruct the testicular blood barrier and will also cause a derangement in contralateral testes blood supply and its cell structure histologically. Anti-oxidants has been used in some studies to prevent further destruction.
To analyze the histopathologic changes in contralateral testes in Wistar rats performed testicular torsion detorsion with and without exogen gluthation as an anti-oxidant.
Fifteen Wistar albino rats, 2–4 months old, weighing 200 – 350 grams, were divided into 2 groups. Group I consists of 7 rats, performed testicular torsion detorsion only. Group II consists of 7 rats performed testicular torsion detorsion and given Tationil Gluthation 25 mg iv, 5 minutes prior to detorsion. Three hours after detorsion, orchidectomy of the contralateral testes were performed in all subjects, and sent for histopathologic examination. Grading of seminiferus tubules damage were evaluated using Cosentino classification and analyzed using Shapiro Wilk test and Mann Whitney test.
Mean of Cosentino grade was 2.71 in group I and 1,57 in group II, with p value 0.01 (p <0.05), proving significant grade difference in both group.
Tationil Gluthation decrease the degree of destruction of seminiferus tubules in contralateral testes of Wistar rats underwent torsion detorsion.
Testicular torsion detorsion, tationil gluthation, histopathology of contralateral seminiferus tubules
