1 Assistant Professor, Department of Pharmacy, Krishna University, Machilipatnam, Andhra Pradesh, India
2Professor and Principle, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, India
3Professor, Department of Chemistry, JNTUA, Anantapuramu, Andhra Pradesh, India
*Corresponding Author: E-mail: dralrao@gmail.com
Online published on 28 July, 2016.
A simple, rapid, precise and accurate RP-HPLC method was developed and validated for the determination of Saroglitazar in tablet dosage form. Separation of the drug was achieved on a Kromasil C18 Column (150 mm x 4.6 mm I.D., 5 μm particle size). The method showed a linear response in the concentration range of 10–60 μg/ml using 0.1% orthophosphoric acid buffer: acetonitrile as the mobile phase in the ratio of 45: 55 v/v with detection at 295 nm with a flow rate of 1 ml/min and retention time was 3.430 min. The method was validated as per the ICH guidelines. The method was successfully applied for routine quality control analysis of Saroglitazar in tablet dosage form.
Saroglitazar, estimation, UV detection, dosage form
