Indian Journal of Pharmacy and Pharmacology
  • Year: 2016
  • Volume: 3
  • Issue: 1

Method Development and Validation for Simultaneous Estimation of Rizatriptan Benzoate and Naproxen Sodium by UV Spectrophotometric Method

  • Author:
  • K Varshini1, Md Mahaboobunnisa1, NB Chandini1, P Apurupa1, PM Latha1, T Prasanthi2,, A Lakshmana Rao3
  • Total Page Count: 6
  • Page Number: 1 to 6

1Student, Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, India

2Assistant Professor, Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, India

3Professor and Principal, Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, India

*Corresponding Author: E-mail: prasanthi8585@gmail.com

Online published on 12 August, 2016.

Abstract

A Simple, validated, accurate and precise simultaneous UV Spectrophotometric method has been developed for the simultaneous estimation of Rizatriptan Benzoate (RIZ) and Naproxen Sodium (NAP) in pharmaceutical dosage form. Rizatriptan Benzoate exhibits absorption maximum at 282.9nm and Naproxen Sodium shows absorption maximum at 261.8nm in methanol. The Beer's law obeyed the concentration range of 5–30μg/ml for RIZ and NAP. Mean recovery of 100.25% for RIZ and 99.2%5 for NAP respectively signifies the accuracy of the method. This method can be used for the routine simultaneous estimation of RIZ and NAP in pharmaceutical dosage forms.

Keywords

Rizatriptan benzoate, Naproxen sodium, Estimation, Spectrophotometry, Dosage form