1Assistant Professor, Dept. of Pharmacology, Narayan Medical College, Jamuhar, Sasaram, Rohtas
2Associate Professor, Dept. of Physiology, Narayan Medical College, Jamuhar, Sasaram, Rohtas
3Professor, Dept. of Physiology, Narayan Medical College, Jamuhar, Sasaram, Rohtas
*Corresponding Author: Email: drashdeo@gmail.com
Online published on 10 October, 2016.
Vitamin D3 has been linked to everything as cancer, diabetes mellitus heart disease etc. One important function of vitamin D is on the beta cells of pancreas that secretes insulin. In cases of deficiency of vitamin D there is not only a decreased secretion of insulin but also increased insulin resistance as proved by various studies. Studies have also shown that treatment of vitamin D deficiency delays the development of insulin resistance & so diabetes mellitus.
Our objective was to examine the association of serum 25-hydroxyvitamin D levels with type 2 diabetes mellitus & effects of vitamin D on it. Analysis were carried out on 200 patients (120 men & 80 women) aged about 35 or above conducted for 1 year in 2014. Diabetes mellitus was defined as fasting plasma glucose > 126mg% or current use of oral hypoglycaemic agents or insulin.
Compared to individuals with a sufficient serum 25(OH)D concentration >75nmol/L, the observed values are divided into 4 groups severe (<25nmol/L), mild (25 to <50 nmol/L), moderate (50 to<75nmol/L) & normal >75nmol/L. The enrolled patients were investigated for blood sugars, vitamin D levels, lipid profiles & HbA1C status at baseline & at the end of 1 year.
Correction of vitamin D deficiency postpones the development of insulin resistance & thus diabetes mellitus & also improves glycemic control.
Vitamin D, Type 2 Diabetes Mellitus, Insulin resistance, HbA1C
