Evaluation of antidepressant effects of rosuvastatin in male albino mice by forced swim test model

To evaluate the antidepressant activity of Rosuvastatin in male albino mice.

Thirty male swiss albino mice were selected for forced swim test model. There were five groups and each group had six animals. The control group received Normal saline (10ml/kg I.P), the standard Imipramine (10mg/kg I.P), the 3 test group received Rosuvastatin (10mg/kg, 15mg/kg, 20mg/kg I.P) respectively. The test was conducted 30mins after injecting the drugs by forced swim test model.

Duration of immobility was noted. Statistical analysis was performed using Mean +/-SEM. One way ANOVA followed by Tukey's post hoc test was done P<0.05 was considered statistically significant.

Rosuvastatin produced significant antidepressant effect at all the doses, as indicated by reduction in the duration of immobility compared to the control and standard with significant p value of <0.0001.

The results of the present study indicates the antidepressant like activity of Rosuvastatin in male albino mice.