Solubility Enhancement of Poorly Water Soluble Drug Aceclofenac

Solid dispersion was aim for increasing solubility and bioavailability of poorly aqueous soluble drug aceclofenac (ACE). Solid dispersion of drug aceclofenac (NSAID) was prepared by using different polymers i.e. Polaxomer 188, PVP k30, PEG 6000, in different ratios 1: 1, 1: 2, 1: 3, by different methods of solid dispersion preparation i.e. Physical method, solvent evaporation method, melt method.

The prepared formulations was characterised by Differential scanning calorimetry (DSC), Scanning electron microscopy (SEM), X-ray diffraction (XRD), In vitro dissolution studies, drug content estimation, saturation solubility. It was concluded that there is change in the crystalline form of drug into amorphous state during formation of solid dispersion.

Polaxomer 188 in ratio 1: 3 through melt method, it shows maximum drug release which is 99.04% in 40 minutes. It was concluded that solid dispersion formation of aceclofenac drug by using polaxomer 188 is promising approach in enhancement of its absorption rate increase bioavailability and minimising its side effects.