Formulation and characterization of ofloxacin opthalmic GEL

Ofloxacin is a fluoroquinolone broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria for the treatment of infections. Ofloxacin is being used as eye drops in the treatment of eye infections. Rapid elimination and poor bioavailability is the disadvantage associated with eye drops. An attempt was made to prolong the retention of ofloxacin in the eye by formulating into gel using HPMC K100, Carbopol 940 and Sodium Alginate individually and in combination and the prepared formulations were evaluated.