1Assistant Professor, GSL Medical College, Rajahmundry, Andhra Pradesh
2Professor, Dept. of Pharmacology, GSL Medical College, Rajahmundry, Andhra Pradesh
3Professor, Dept. of Pharmacology, IMS & SUM Hospital, SOA University, Bhubaneswar, India
*Corresponding Author: Email: sanjaykumarimssum@gmail.com
Online published on 3 January, 2019.
To know adverse drug reactions when Aspirin is prescribed with Antihypertensive medications.
Prospective observational study conducted in a tertiary care hospital, total 60 patients of age group 18 to 65 years were included in the study, It is a 12 week study, clinical examination done at enrollment and with subsequent follow up at 4, 8 and 12 weeks, Base line investigations done at enrollment and at 12 weeks, ADR monitoring done at each follow up Casuality assessment of all ADRs was done by Naranjo ADR scale
Out of 45 patients who experienced adverse effects, causality assessment shows that Aspirin is responsible for producing ADRs in 15 patients and in remaining 30 patients, Aspirin interaction is likely cause for ADRs, Incidence of adverse effects is 40% in Aspirin with concomitant Betablocker therapy and 26% in Aspirin with thiazide diuretics and 16% in aspirin with ACE inhibitors or Calcium channel blockers
This study shows increased incidence of Adverse drug reactions (though these are mild ADRs) when Aspirin is added to Betablockers and Thiazide diuretics in treatment of hypertension, Incidence of ADRs is high in elderly patients,
Aspirin, Betablockers, Calcium channel blockers, ACE inhibitors, Thiazide diuretics, Naranjo scale
