Effect of enrofloxacin on chicken chromosome: A comparative study

Enrofloxacin (EFC) is a fluorinated 4-quinolone antibiotic, which is effective against a wide spectrum of gram positive and negative organisms including anacerobic populations. It inhibits the bacterial gyrase and in high concentrations also the functionally related eukaryotic topoisomerase-II, which results in genotoxicity of the test system; chromosomal anomalies in chicken. In treatment with doses 5 x (times,), 10X, 15X, the curative dose of EFX (Curative does 1ml/kg of body weight, 1 ml contains 1mg of EFX). For bacterial treatment, it was found that occurrence of the different aberrations are more in WL chicken chromosomes than Dwarf (Dw) chicken (evolved at “All Indian Co-ordinated Research on Poultry, JNKVV, Jabalpur”).

As the chickens are exposed to an excess of drug EFX, because they may take in higher dose through water particularly during summer months, this investigation of the higher doses of the drug will be much use for the dosing severe infection in poultry industry.