Effect of dietary ochratoxin on biochemical and antioxidant profile in broiler chickens

Twelve newly hatched broiler chicks were randomly allotted to two groups (Control-6 Nos. and 100 ppb ocharatoxin A (OA) toxin fed group-6 birds) and maintained up to 28 days of days. On 28^th day, all the birds from both the groups were sacrificed to study the serum biochemical alterations and liver antioxidant profile. Significant (P<0.05) decrease was observed in the globulin and A: G ratio in the OA fed group. Hypoglycaemia, hypoamylasaemia, reduction in HDL, elevation in ALT, ALP, BUN, triglycerides, VLDL and TC/HDL ratio were observed in the OA fed group. No significant differences were observed between the control and OA fed group in the total protein, albumin, AST, GGT, creatinine, uric acid, total cholesterol, LDL and lipase. TBaRs levels of liver were increased significantly (P<0.05) in the OA fed group compared to the control group. SOD, catalase, GPx, GSH and GST levels were decreased significantly (P<0.05) in the liver of OA fed birds compared to the control group. Biochemical alterations indicated the hepatocellular damage, renal damage and alimentary tract pathology. Antioxidant profile revealed that hepatocellular degeneration and oxidative stress. It was concluded that dietary dose of 100 ppb ochratoxin caused liver and kidney dysfunctions, hypoglycaemia, increased liver lipid peroxidation and decreased antioxidant levels.