Pharmaceutical Significance of Copper (II), Nickel (II), Ruthenium (III) and Manganese (II) Complexes of Schiff Bases Derived from Thiosemicarbazones

This article illustrates the synthesis, characterization and biological activities of schiff bases and their metal complexes. Researches indicate thiosemicarbazone metal chelation properties forming coordination sym metrical structures including tetrahedral, square planar, as well as octahedral complexes. Metal complexes formed by the interaction of bis(3-bromo-4-hydroxybenzaldehyde) and lbis (4-chlorobenzaldehyde) have been prepared. These complexes have been identified by their IR, electronic, molar, and magnetic moment spectra. Carbonyl group, metal and solvents play a dominant role in the formation of coordination transition metal complexes. Thiosemicarbazones are ligands formed by Schiff bases and have been screened for wide range of pharmaceutical properties like antimicrobial and anticarcinogenic. Metals show binding effects on the target cells to influence the biochemical properties in animals, these complexes show proliferative biological properties on chelation. Electronic arrangements and structure of the complex is related to activity of biomolecules. The coordination of the ligand with a metal ion is related to antibacterial, antifungal, anticancer, anti-inflammatory, antitumour and anticancer activities.