International Journal of Research in Engineering and Applied Sciences
  • Year: 2015
  • Volume: 5
  • Issue: 6

Synthesis, biological activity and structural investigation of some new 2 – amino -4 -(P-ethoxy phenyl) thiazole derivatives

  • Author:
  • Dinkar Malik
  • Total Page Count: 5
  • Page Number: 216 to 220

Department of Chemistry, M. S. College, Saharanpur, U.P.

Online published on 20 July, 2015.

Abstract

The complexes of the type ML2X2 (where M = Cu (II), Co (II) and Ni (II), L= 2-amino-4-(p-ethoxy phenyl) thiazole and X= Ci,NO3 were prepared and characterized on the basis of IR, elemental analysis, electronic and magnetic susceptibility studies. The complexes were ionic and octahedral which show significant covalency in metal-ligand bond. IR studies have shown that nitrogen of the amino group and sulphur of the thiazole ring took part in co-ordination. All the synthesized complexes were screened for their antifungal activity against different fungi at different concentrations. The activity decreases with decrease of concentration and the metal complexes are less toxic than the parent ligand.

Keywords

Octahedral Complexes, Elemental Analysis, Thiazole ligand, Toxicity