International Journal of Research in Engineering and Applied Sciences

Several herbal preparations are use to get rid of diabetes, but their reported hypoglycaemic effects are complex. The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal com-munity but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, antimicrobial, anti inflammatory, anti-oxidant, aphrodisiac, antihelmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer In this studies the histological changes and carbohydrate profile in Alloxan-induced diabetes in rat treated with the leaf gel of Aloe vera ethanol extract on was evaluated. Twenty eight male rats were used in the study by allocating them into four groups, each of seven rats. Control rats, control rats + Aloe vera, diabeticblack rats, diabetic + Aloe vera. Diabetes was induced intra peritoneally using 50 mg/kg body weight Alloxan. Aloe vera leaf gel extract administered orally to different groups of rat at a dose of 300 mg mg/kg body weight. The experimental period was 25days. The parameters studied are total carbohydrates, glycogen and glucose and histopathological changes of testis were investigated compared to the control group. These metabolic profiles were decreased in diabetic rats, expect glucose. Whereas, with Aloe vera extract treatment in diabetic rats these carbohydrate metabolic profiles were increased and glucose decreased. The observed reductions in carbohydrate metabolic profiles during diabetic condition in testis tissue may be due to the alterations in the carbohydrate metabolism. Aloe vera is capable of producing free radicles, which in turn cause damage to the cellular compartment system of black rat(Rattus rattus,).